Casamayor Retains Super-Featherweight Crown
Casamayor recorded the only knockdown of the bout in the second round as he dropped Santana en route to a dominant performance.
"I came to work 12 rounds," Casamayor said. "I feel good. I did what I had to do to win. I came in and did my work."
Two of the three judges gave every round to the champion in scoring the bout 120-107, while the third judge gave one of those rounds to Santana and scored it, 119-108.
With the victory, Casamayor (25-0) is now on collision course for a July "unification" fight with the undefeated Brazilian Acelino Fretias, who holds the WBO version of the title, Reuters reported.
Big-punching Fretias (29-0, 29 KOs) was scheduled to appear on the card, but withdrew for his fight on Tuesday citing personal reasons.
A standout amateur, Casamayor compiled a 380-30 record and won the gold medal at the 1992 Olympics in Barcelona.
A medal favorite to repeat in Atlanta four years later, Casamayor defected from the Cuban boxing team in Mexico before the 1996 Summer Games.
He captured a share of the WBA crown in June 1999 with a victory over Mexico's Antonio Hernandez.
Casamayor later would become the first member of "Team Freedom" to win a world title when he captured the WBA super featherweight championship with a fifth-round stoppage on cuts of South Korea's Jongwon Baek on May 21, 2000.
"Team Freedom" consists of a group of 13 former Cuban amateurs who defected to the United States to become professional boxers.
Casamayor has successfully retained his title with stoppage victories over Radford Beasley (TKO 5) and former IBF junior lightweight champ Roberto Garcia (TKO 9).
Santana fell to 27-4-5.