TEHRAN-- Transplantation of hematopoietic stem cell is today an established therapy for a variety of congenital or acquired severe disorders of the hematopoietic system as well as for chemo-or radiosensitive malignancies. In the last decade with better definition of human leukocyte antigen (HLA) system and the immunology of transplantation, improved clinical results have led to use of hematopoietic transplantation at earlier stages of the natural history of several diseases. Allogeneic stem cell transplantation as a curative treatment for disorders of hematopoietic system and chemo-senstive of malignancies was established in Shiraz University of Medical Sciences in 1993. In this report we describe 9 years experience of allogeneic bone marrow transplantation in our center in the south of Iran.